The Spectrum of Fungal Colonization and Their Attributable Effects on Cystic Fibrosis Patients with Rare CFTR Genetic Mutations

Chronic airway colonization by bacteria and fungi is very common in CF patients, causing irreversible lung damage. It known that rates of fungal infections are much lower than those bacterial infections, however they can worsen the medical condition patients. In this study, we identify most species isolated from 31 adult patients Qatar analyze their correlation with function, pulmonary exacerbations, bronchial asthma, pancreatic insufficiency. Mycological evaluation, as well records, were reviewed for regularly under service at Hamad General Hospital period between 2017–2019. All included study carry rare CFTR mutations. The majority (n = 25) carried c.3700A>G; I1234V mutation, whereas three heterozygous mutation (c.1657C>T c.1115A>T) remaining homozygous (c.920G>A). Twenty-two participants (70.9%) colonized regardless type mutation. Candida Aspergillus common, colonizing 81% 45% respectively. For dubliniensis was frequently reported (55.6%), fumigatus (50.0%) among These identified pathogens associated poor insufficiency, asthma cohort. Such could possibly aggravate complications, notably