The small chill: mild hypothermia for cardioprotection?
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چکیده
منابع مشابه
The small chill: mild hypothermia for cardioprotection?
Reducing the heart's temperature by 2-5°C is a potent cardioprotective treatment in animal models of coronary artery occlusion. The anti-infarct benefit depends upon the target temperature and the time at which cooling is instituted. Protection primarily results from cooling during the ischaemic period, whereas cooling during reperfusion or beyond offers little protection. In animal studies, pr...
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Reducing core temperature to protect the injured brain has become a new therapeutic measure. The scientific underpinnings based on animal experiments seem sound. Evidence of the therapy's effect in human trials is insufficient or even possibly absent, but the techniques to produce moderate hypothermia are available, without apparent significant complications, and are relatively easy to use for ...
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references 1. Hatwalne MS. Free radical scavengers in anaesthesiology and critical care. Indian J Anaesth 2012;56:227‐33. 2. Pham‐Huy LA, He H, Pham‐Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci 2008;4:89‐96. 3. Kikuchi K, Miura N, Kawahara KI, Murai Y, Morioka M, Lapchak PA, et al. Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to t...
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Physicians commonly ignore hypothermia, an often-underappreciated event associated with mortality in trauma patients, in general due to its prevalence and belief that it is secondary to the injury itself (secondary hypothermia). Over the past several decades, hypothermia in trauma has been studied concerning its effects on mortality; however, very little has been done to identify the major risk...
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Mild therapeutic hypothermia of 32-35°C improved neurologic outcomes in outside hospital cardiac arrest survivor. Furthermore, in experimental studies on infarcted model and pilot studies on conscious patients with acute myocardial infarction, therapeutic hypothermia successfully reduced infarct size and microvascular resistance. Therefore, mild therapeutic hypothermia has received an attention...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2010
ISSN: 0008-6363
DOI: 10.1093/cvr/cvq227