The signal pathway of gonadotrophins-induced mammalian oocyte meiotic resumption
نویسندگان
چکیده
منابع مشابه
The signal pathway of gonadotrophins-induced mammalian oocyte meiotic resumption.
Fully grown mammalian oocytes are arrested at the first meiotic prophase until a surge of gonadotrophin at the mid-cycle. The actions of gonadotrophins, follicle stimulating hormone (FSH) and luteinizing hormone (LH), on oocyte meiotic resumption are believed to be mediated in large part through increasing the production of cyclic adenosine 3',5'-monophosphate and subsequent activation of mitog...
متن کاملGonadotropin-controlled mammal oocyte meiotic resumption.
Fully grown mammalian oocytes resume meiosis as a consequence of rises in gonadotropin levels at the mid-cycle. The increase of cyclic adenosine 3',5'-monophosphate (cAMP) and the activation of protein kinase A (PKA), protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) in cumulus cells are required for gonadotropins-induced meiotic resumption of oocytes. The various actions of cA...
متن کاملThe Control of Meiotic Arrest and Resumption in Mammalian Oocytes
In mammals, following implantation of the embryo, a small number of cells from the epiblast eventually become the precursors of primordial germ cells (reviewed by Edson et al., 2009). After mitotic proliferation of the primordial germ cells, migration to the genital ridges and rapid proliferation again, meiosis is initiated in the oogonia at about day 13 of development in mice, at day 82 in bov...
متن کاملNPR2 is involved in FSH-mediated mouse oocyte meiotic resumption
BACKGROUND Previous studies have reported that follicle-stimulating hormone (FSH) is often added to culture media to induce oocyte meiotic resumption and maturation and to improve subsequent embryonic development during in vitro maturation (IVM). However, the underlying mechanisms remain unclear. METHODS Cumulus-oocyte complexes (COCs) were collected from ovaries 46-48 h after the female mice...
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In the mammalian oocyte, distinct patterns of centromeres and pericentromeric heterochromatin localisation correlate with the gamete's developmental competence. Mouse antral oocytes display two main types of chromatin organisation: SN oocytes, with a ring of Hoechst-positive chromatin surrounding the nucleolus, and NSN oocytes lacking this ring. When matured to MII and fertilised, only SN oocyt...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2009
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/gap031