The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes

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Plasma Glucose Concentration and Prediction of Future Risk of Type 2 Diabetes

The prevalence of type 2 diabetes has increased in recent decades to epidemic proportions. About 150 million individuals worldwide had type 2 diabetes in 2000, and this number is expected to increase to 300 million by the year 2025 (1). Because of the chronic course of type 2 diabetes and the significant morbidity and mortality associated with the vascular complications of the disease, type 2 d...

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Fasting Versus Postload Plasma Glucose Concentration and the Risk for Future Type 2 Diabetes

OBJECTIVE The purpose of this study was to assess the efficacy of the postload plasma glucose concentration in predicting future risk of type 2 diabetes, compared with prediction models based on measurement of the fasting plasma glucose (FPG) concentration. RESEARCH DESIGN AND METHODS A total of 2,442 subjects from the Botnia Study, who were free of type 2 diabetes at baseline, received an or...

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Changes in plasma nitric oxide metabolites concentration during glucose tolerance test in type 2 diabetic rats

Introduction: Repeated hyperglycemia play an important role in the development of atherosclerosis in diabetic patients. Endothelium is the organ of the first-line defense against atherosclerosis and nitric oxide has a major role in this task. The aim of this study was to determine changes in plasma nitric oxide metabolites concentration during glucose tolerance test in type 2 diabetic rats. Me...

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Patterns of Insulin Concentration During the OGTT Predict the Risk of Type 2 Diabetes in Japanese Americans

OBJECTIVE To examine whether the patterns of insulin concentration during the oral glucose tolerance test (OGTT) predict type 2 diabetes. RESEARCH DESIGN AND METHODS We followed 400 nondiabetic Japanese Americans for 10-11 years. Insulin concentrations at 30, 60, and 120 min during a 2-h 75-g OGTT at baseline were used to derive the following possible patterns of insulin: pattern 1 (30-min pe...

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Tryptophan Predicts the Risk for Future Type 2 Diabetes

Recently, 5 amino acids were identified and verified as important metabolites highly associated with type 2 diabetes (T2D) development. This report aims to assess the association of tryptophan with the development of T2D and to evaluate its performance with existing amino acid markers. A total of 213 participants selected from a ten-year longitudinal Shanghai Diabetes Study (SHDS) were examined...

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ژورنال

عنوان ژورنال: Diabetes/Metabolism Research and Reviews

سال: 2010

ISSN: 1520-7552,1520-7560

DOI: 10.1002/dmrr.1084