The serine protease inhibitors and plant-insect interaction
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چکیده
منابع مشابه
Glycosaminoglycans: Synthetic fragments and their interaction with serine protease inhibitors
Glycosaminoglycans such as e.g. heparin, heparan sulphate and dermatan sulphate display a broad variety of biological activities. Unique, Well-defined domains in some glycosaminoglycans have been characterized that are responsible for the biological activity. For instance, a unique pentasaccharide domain in heparin could be identified which binds and activates the serine protease inhibitor (ser...
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Unlike most globular proteins, the native form of serine protease inhibitors (serpins) is strained. Previous studies of human alpha(1)-antitrypsin, a prototype plasma serpin, revealed that various unfavorable interactions, such as overpacking of side chains, buried polar groups and cavities, are the structural basis of the strain. The local strain could be relieved by various stabilizing single...
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It has been recognized for many years that the nutritive value and protein digestibility of many plant proteins, particularly those derived from legumes, are very poor unless subjected to cooking or some other form of heat treatment (Liener & Kakade, 1969). This beneficial effect of heat has beem generally attributed, at least in part, to the destruction of a unique class of proteins which have...
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The study of plant–insect interactions continues to be an exciting and fast-moving field that builds upon the more extensive literature available in plant–microbe interactions and offers new and significant insights into both the unique molecular determinants of plant–insect interactions and the wider ecological context. This special issue of the Journal of Experimental Botany brings together a...
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Three inhibitors that are based upon a 4-heterocyclohexanone nucleus were synthesized and evaluated for activity against the serine protease plasmin. Inhibitors of plasmin have potential as cancer chemotherapeutic agents that act by blocking both angiogenesis and metastasis. Inhibitor 1 has moderate activity against plasmin but shows good selectivity for this enzyme compared to other serine pro...
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ژورنال
عنوان ژورنال: Idesia (Arica)
سال: 2012
ISSN: 0718-3429
DOI: 10.4067/s0718-34292012000100015