منابع مشابه
Illuminating the secretory pathway
Proteins destined for secretion, the plasma membrane or membranous cellular organelles enter the secretory pathway in the endoplasmic reticulum (ER) and move via the Golgi complex to the trans-Golgi network, where they are sorted and transported to their final destination. Malfunction in this pathway may lead to the breakdown of cellular organelles, cell polarity, overall cellular architecture ...
متن کاملSecretory protein biogenesis and traffic in the early secretory pathway.
The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum (ER), which is charged with the tasks of correctly integrating nascent proteins and ensuring correct post-translational modification and folding. Once ready for forward traffic, proteins are captured into ER-derive...
متن کاملUpdate on the Secretory Pathway of Plants What Is Moving in the Secretory Pathway of Plants?
The secretory pathway of eukaryotic cells is a fascinating system of membrane compartments in dynamic equilibrium from the constant budding and fusion of vesicles and other membrane-enclosed transport carriers. Compared to yeasts, the plant protein machinery controlling vesicle budding, tethering, and fusion appears to be more complex and comparable to that of multicellular metazoans, confirmin...
متن کاملThe dynamic organisation of the secretory pathway.
The secretory pathway of eukaryotic cells consists of a number of distinct membrane-bound compartments interconnected by vesicular traffic. Each compartment has a characteristic content of proteins and lipids, which must be maintained. This is achieved in most cases by active sorting-proteins may reach the wrong compartment but are continually retrieved. A good example is the retrieval system f...
متن کاملThe casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p
Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P). Sec2p also binds to the Sec4p effector Sec15p, yet Ypt32p and Sec15p compete against each other for binding to Sec2p. We report here that the ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
سال: 2015
ISSN: 1570-9639
DOI: 10.1016/j.bbapap.2015.03.015