The RTS,S malaria vaccine

Designing a malaria vaccine.

Malaria vaccine developments.

Large gains in the reduction of malaria mortality in the early 20th century were lost in subsequent decades. Malaria now kills 2-3 million people yearly. Implementation of malaria control technologies such as insecticide-treated bednets and chemotherapy could reduce mortality substantially, but an effective malaria vaccine is also needed. Advances in vaccine technology and immunology are being ...

Malaria vaccine boost

For decades detailed molecular biology about malaria has been accrued: but, throughout this time, the most effective measures in regions where the disease is endemic have continued to rely on the chemical and physical methods of insecticides and bednets, with drugs available to people travelling to these regions. So the latest study to test a new malaria vaccine developed by GlaxoSmithKline (GS...

The challenges of introducing a malaria vaccine

For the first time a malaria vaccine is to be tested for possible inclusion in national immunization programmes. Malcolm Molyneux tells Fiona Fleck why governments may need to work hard to convince people of its benefits.

Evaluating the efficacy of a malaria vaccine.

Malaria is a major public health problem. An effective vaccine against malaria is actively being sought. We formulate a potential outcomes definition of the efficacy of a malaria vaccine for preventing fever. A challenge in estimating this efficacy is that there is no sure way to determine whether a fever was caused by malaria. We study the properties of two approaches for estimating efficacy: ...