The Role of NMDARs Ligands on Antinociceptive Effects of Pregabalin in the Tail Flick Test
نویسندگان
چکیده
منابع مشابه
the role of nmdars ligands on antinociceptive effects of pregabalin in the tail flick test
conclusions our findings support the role of nmdars in pregabalin antinociception, because the nmdar agonist, unlike the antagonist, decreased the antinociceptive effect of pregabalin, even if tail flick is not an adequate pain assessment method in this regard. background pregabalin as a new anticonvulsant has been used in different pain treatments. objectives the aim of this study was to inves...
متن کاملThe Role of NMDARs Ligands on Antinociceptive Effects of Pregabalin in the Tail Flick Test
BACKGROUND Pregabalin as a new anticonvulsant has been used in different pain treatments. OBJECTIVES The aim of this study was to investigate the role of N-methyl-D-aspartate (NMDA) ligands in antinociceptive effect of pregabalin in mice using tail flick. MATERIALS AND METHODS NMDA (15 and 30 mg/kg) as an agonist or MK801 (0.02 and 0.05 mg/kg) as an antagonist were injected intraperitoneall...
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15 صفحه اولEvaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test
The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...
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ژورنال
عنوان ژورنال: Anesthesiology and Pain Medicine
سال: 2015
ISSN: 2228-7523,2228-7531
DOI: 10.5812/aapm.28968