The Role of Citrus Nobiletin on Oxidative Stress Levels and Superoxide Dismutase Activities in Metastatic Castration-Resistant Prostate Cancer
نویسندگان
چکیده
Nobiletin (NOB) is a polymethoxylated flavone. It has multiple biologic activities that can modulate oxidative stress in many cancer types. However, there no study the literature examined effects of NOB on levels Metastatic Castration-Resistant Prostate Cancer (MCRPC) yet. Motivated from this gap, we investigated impact and superoxide dismutase (SOD) enzyme MCRPC as preliminary study. For purpose, PC-3 HUVEC cells were used to determine amount Malondialdehyde (MDA), hydrogen peroxide (H2O2), proline well SOD activities. potentially induced but level MDA, H2O2, decreased after incubation with (p<.05 p<.001 considered statistically significant). Our results confirmed acted protective agent for could selectively regulate oxidant status cells. Consequently, these findings provide better insight into role citrus antioxidant MCRPC. Additionally, need elucidate molecular mechanisms cytoprotective effect potential chemotherapeutic agent.
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ژورنال
عنوان ژورنال: Commagene journal of biology
سال: 2021
ISSN: ['2602-456X']
DOI: https://doi.org/10.31594/commagene.895415