The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review

Background: Several studies have been conducted to prove the bidirectional relationship between cardiovascular disease (CVD) and depression. These two major illnesses share several common risk factors such that development of either condition may increase occurrence other. Brain-derived neurotrophic factor (BDNF) has suggested as a reliable biomarker for depression strong predictor CVD because it plays an important role in neuron survival growth, serves neurotransmitter modulator, promotes neuronal plasticity. The aim this systematic review was examine depression, focusing on potential low serum BDNF levels presence Methods: A search strategy developed using PRISMA guidelines. Results: Six (comprising 1251 patients) were identified, all which examined association Conclusions: It found there be post-stroke However, altered other types are few. Therefore, inverse cannot proven.