The resistance mechanisms of proteasome inhibitor bortezomib
نویسندگان
چکیده
منابع مشابه
Bortezomib / proteasome inhibitor PS - 341 resistance in multiple myeloma
198 words; Text4628 words Blood First Edition Paper, prepublished online June 24, 2004; DOI 10.1182/blood-2004-02-0547 Copyright (c) 2004 American Society of Hematology only. For personal use at PENN STATE UNIVERSITY on February 23, 2013. bloodjournal.hematologylibrary.org From
متن کاملNoncompetitive Proteasome inhibition on Bortezomib resistance
The proteasomal degradation pathway rids cells of excess and misfolded proteins and regulates the cellular levels of proteins that are responsible for processes, such as cell cycle progression, DNA repair, and transcription [reviewed in (1)]. The proteasomal pathway of protein degradation is initiated by the sequential enzymatic activities of ubiquitin ligases E1, E2, and E3, which add chains o...
متن کاملThe proteasome inhibitor bortezomib enhances the susceptibility to viral infection.
The proteasome, a multicatalytic protease, is responsible for the generation of most MHC class I ligands. Bortezomib, a proteasome inhibitor, is clinically approved for treatment of multiple myeloma and mantle cell myeloma. In the present study, we investigated the effect of bortezomib on viral infection. Infection of bortezomib-treated mice with the lymphocytic choriomeningitis virus (LCMV) le...
متن کاملThe proteasome inhibitor bortezomib aggravates renal ischemia-reperfusion injury.
Bortezomib is a well-established treatment option for patients with multiple myeloma (MM). It is a selective and reversible inhibitor of the proteasome that is responsible for the degradation of many regulatory proteins that are involved in apoptosis, cell-cycle regulation, or transcription. Because patients with MM are prone to develop acute renal failure, we evaluated the influence of bortezo...
متن کاملBlockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells.
Bortezomib (PS-341), a selective inhibitor of proteasome, induces apoptosis in various tumor cells, but its mechanism of action is unclear. Treatment with PS-341 induces apoptosis in SUDHL6 (DHL6), but not SUDHL4 (DHL4), lymphoma cells. Microarray analysis shows high RNA levels of heat shock protein-27 (Hsp27) in DHL4 versus DHL6 cells, which correlates with Hsp27 protein expression. Blocking H...
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ژورنال
عنوان ژورنال: Biomarker Research
سال: 2013
ISSN: 2050-7771
DOI: 10.1186/2050-7771-1-13