THE RECOVERABILITY OF VIRUS FROM PAPILLOMAS PRODUCED THEREWITH IN DOMESTIC RABBITS

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The Recoverability of Virus from Papillomas Produced Therewith in Domestic Rabbits

By preliminary preparation of the skin in ways that render it hyperplastic the presence of infective virus can be demonstrated in extracts of domestic rabbit papillomas which yield no growths when inoculated by the ordinary methods and which for this reason have been supposed to contain no virus. The amount of virus recovered by the method outlined in the present work, however, is small when co...

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Induction of Tumors in Domestic Rabbits with Nucleic Acid Preparations from Partially Purified Shope Papilloma Virus and from Extracts of the Papillomas of Domestic and Cottontail Rabbits

A deoxyribonucleic acid preparation which showed infectivity and tumorigenic activity in domestic rabbits was isolated from the papillomatous tissue of wild cottontail rabbits by phenolic deproteinization procedure. The activity of the preparation could be completely abolished by its exposure to a minute amount (0.02 microg/ml) of DNAase. Antisera against Shope papilloma virus did not block the...

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Immunological Reactions with a Virus Causing Papillomas in Rabbits

A study has been made of the yield of virus and of the complement-binding antigen from the virus-induced papillomas of cottontail and domestic rabbits. Extracts of the discrete, naturally occurring papillomas of cottontail rabbits usually contain virus in large amount; and, as a rule, they also contain the complement-binding antigen in high titer. The confluent growths produced experimentally w...

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Virus content of Shope papillomas of cottontail rabbits.

The virus content of naturally occurring and experimentally induced papillomas of cottontail rabbits varies considerably. As a rule different individual papillomas on the same rabbit were found to have a similar virus content. The amount of virus usually increased as the tumors aged from 6 to 12 weeks. After 12 weeks there was no consistent pattern of change in virus con tent of papillomas, and...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1944

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.79.6.591