The Quest for Targets Executing MYC-Dependent Cell Transformation

The Quest for Targets Executing MYC-Dependent Cell Transformation

MYC represents a transcription factor with oncogenic potential converting multiple cellular signals into a broad transcriptional response, thereby controlling the expression of numerous protein-coding and non-coding RNAs important for cell proliferation, metabolism, differentiation, and apoptosis. Constitutive activation of MYC leads to neoplastic cell transformation, and deregulated MYC allele...

Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation.

Myc oncoproteins are overexpressed in most cancers and are sufficient to accelerate cell proliferation and provoke transformation. However, in normal cells Myc also triggers apoptosis. All of the effects of Myc require its function as a transcription factor that dimerizes with Max. This complex induces genes containing CACGTG E-boxes, such as Ornithine decarboxylase (Odc), which harbors two of ...

Cannabidiol in Humans—The Quest for Therapeutic Targets

Cannabidiol (CBD), a major phytocannabinoid constituent of cannabis, is attracting growing attention in medicine for its anxiolytic, antipsychotic, antiemetic and anti-inflammatory properties. However, up to this point, a comprehensive literature review of the effects of CBD in humans is lacking. The aim of the present systematic review is to examine the randomized and crossover studies that ad...

A random walk in oncogene space: the quest for targets.

Introduction Oncogenes code for components of cellular growth-regulatory signals (1, 2). Such signals typically start at the cell surface, traverse the cytoplasm, and then terminate in the nucleus. They are propagated by protein-protein interactions between modular recognition domains and controlled by conformational changes and protein phosphorylation. The oncogenic potential of these growth-r...

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