منابع مشابه
The protein folding problem.
The "protein folding problem" consists of three closely related puzzles: (a) What is the folding code? (b) What is the folding mechanism? (c) Can we predict the native structure of a protein from its amino acid sequence? Once regarded as a grand challenge, protein folding has seen great progress in recent years. Now, foldable proteins and nonbiological polymers are being designed routinely and ...
متن کاملTowards Solving the Inverse Protein Folding Problem
Accurately assigning folds for divergent protein sequences is a major obstacle to structural studies and underlies the inverse protein folding problem. Herein, we outline our theories for fold-recognition in the “twilight-zone” of sequence similarity (<25% identity). Our analyses demonstrate that structural sequence profiles built using Position-Specific Scoring Matrices (PSSMs) significantly o...
متن کاملThe protein folding problem: a biophysical enigma.
Protein folding, the problem of how an amino acid sequence folds into a unique three-dimensional shape, has been a long-standing problem in biology. The success of genome-wide sequencing efforts has increased the interest in understanding the protein folding enigma, because realizing the value of the genomic sequences rests on the accuracy with which the encoded gene products are understood. Al...
متن کاملSimple Models of the Protein Folding Problem
The protein folding problem has attracted an increasing attention from physicists. The problem has a avor of statistical mechanics, but possesses the most common feature of most biological problems – the profound e ects of evolution. I will give an introduction to the problem, and then focus on some recent work concerning the so-called “designability principle”. The designability of a structure...
متن کاملInverse Protein Folding Problem via Quadratic Programming
This paper presents a method of reconstruction a primary structure of a protein that folds into a given geometrical shape. This method predicts the primary structure of a protein and restores its linear sequence of amino acids in the polypeptide chain using the tertiary structure of a molecule. Unknown amino acids are determined according to the principle of energy minimization. This study repr...
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ژورنال
عنوان ژورنال: Annual Review of Biophysics
سال: 2008
ISSN: 1936-122X,1936-1238
DOI: 10.1146/annurev.biophys.37.092707.153558