The prejunctional actions of some non-depolarizing blocking drugs
نویسندگان
چکیده
منابع مشابه
Interactions between suxamethonium and non-depolarizing neuromuscular blocking drugs.
In anaesthetized cats, we have confirmed that previously injected suxamethonium potentiates non-depolarizing neuromuscular blocking drugs whereas, when injected during the block, suxamethonium antagonizes the paralysis. We have attempted to explain these interactions by studying the effects of suxamethonium on extracellularly recorded nerve ending waveforms that correspond to the ionic currents...
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When a clinical dose of a competitive neuromuscular blocking drug is given I.V. to a patient, a period of latency is followed by a progressive onset of blockade until a maximum is reached after several minutes. Thereafter, the intensity of block declines gradually. The precise relationship between the dose of drug and the time-course of the effect is complex, being dependent upon both pharmacok...
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were taken from this mixture at nine intervals for up to 128 min. Each sample was immediately acidified, stored at — 20 °C and subsequently transferred to Groningen for analysis. All samples revealed vecuronium without any of its breakdown products. Unlike the 3-hydroxy metabolite, neither of the two other metabolites of vecuronium (17-hydroxy and 3,17-dihydroxy vecuronium) have been detected p...
متن کاملInteraction of sevoflurane, isoflurane, enflurane and halothane with non-depolarizing muscle relaxants and their prejunctional effects at the neuromuscular junction.
The interaction of four inhalational anesthetics (sevoflurane, isoflurane, enflurane and halothane) with pancuronium and vecuronium and also their prejunctional actions at the neuromuscular junction were quantitatively studied using rat phrenic nerve-hemidiaphragm preparations. To investigate the prejunctional effects of inhalational anesthetics, a train-of-four ratio (T4/T1) and the tetanus ra...
متن کاملEffects of non-depolarizing neuromuscular blocking agents on the cardiac vagus nerve in the guineapig.
The ability of gallamine, metocurine, pancuronium, tubocurarine and atropine to block the response to postganglionic stimulation of the vagus nerve were measured in isolated, spontaneously beating guineapig atria. From analysis of the results in conjunction with those of earlier assays of concentrations that block effects of preganglionic vagal stimulation, it was concluded that only tubocurari...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1973
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1973.tb08163.x