The potential role of Simian Virus 40 polyA sequence (SV40 polyA) to mediate stress‐inducible mRNA translation
نویسندگان
چکیده
منابع مشابه
Simian Virus 40 (SV40) and Human Cancers
Simian virus 40 (SV40) contaminated the early poliovirus vaccines used throughout much of the world during the late 1950’s and early 1960’s. SV40 is oncogenic in rodents and can transform human cells in vitro. Most epidemiologic studies, however, have failed to detect increased risks of cancer among those exposed to SV40-contaminated poliovirus vaccines, even after more than 30 years of follow-...
متن کاملA sequence motif in the simian virus 40 (SV40) early core promoter affects alternative splicing of transcribed mRNA.
To identify new sequence elements in the promoter that affect splicing patterns of pre-mRNAs, we analyzed effects of different promoters on alternative splicing of model reporter genes. We compared the E1a alternative splicing pattern in transcripts expressed from the full-length cytomegalovirus, SV40 early, or a hybrid cytomegalovirus/SV40 early promoter and found that the hybrid promoter impr...
متن کاملEffect of mutations in a simian virus 40 PolyA signal enhancer on green fluorescent protein reporter gene expression.
Our previous studies have shown that tandem Alu repeats inhibit green fluorescent protein (GFP) gene expression when inserted downstream of the GFP gene in the pEGFP-C1 vector. We found that the 22R sequence (5'-GTGAAAAAAATGCTTTATTTGT-3') from the antisense PolyA (240 bp polyadenylation signal) of simian virus 40, eliminated repression of GFP gene expression when inserted between the GFP g...
متن کاملThe Influence of SV40 polyA on Gene Expression of Baculovirus Expression Vector Systems
The simian virus 40 polyadenylation signal (SV40 polyA) has been routinely inserted downstream of the polyhedrin promoter in many baculovirus expression vector systems (BEVS). In the baculovirus prototype Autographa californica multiple nucleopolyhedrovirus (AcMNPV), the polyhedrin promoter (very late promoter) transcribes its gene by a viral RNA polymerase therefore there is no supporting evid...
متن کاملGeorge Polya
The undisputed father of mathematical problem solving is George Pólya (December 13, 1887 – September 7, 1985), one of the giants of classical analysis in the 20 century. He considered solving problems to be a practical art, one that can be taught and learned. His books on the subject How To Solve It (1945) and the two-volume set Mathematics and Plausible Reasoning (1954), and Mathematical Disco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.551.3