The potential molecularly therapy target to <i>MYCN</i>‐amplificated neuroblastoma
نویسندگان
چکیده
Abstract Neuroblastoma (NB) is an embryonal deadly cancer in childhood driven by MYC or MYCN‐driven oncogenic signaling. The amplification of MYCN leads to malignant progression NB and poor prognosis. Traditional chemotherapy still a standard treatment for NB. Most the cytostatic drugs take function anti‐neuroblastoma. However, children with exhibit different clinical outcome variability biological characteristics compared adult patients. Given this, it urgent need explore novel, safer more efficacious treatments.
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ژورنال
عنوان ژورنال: Clinical and translational discovery
سال: 2023
ISSN: ['2768-0622']
DOI: https://doi.org/10.1002/ctd2.237