The Possible Role of TLR2 in Chronic Hepatitis B Patients with Precore Mutation
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چکیده
منابع مشابه
The Possible Role of TLR2 in Chronic Hepatitis B Patients with Precore Mutation
Recognition mechanisms of innate immune response help to improve immunotherapeutic strategies in HBeAg-negative chronic hepatitis B (CHB). Toll-like receptor 2 (TLR2) is an important component of innate immunity. In this study, the frequency of precore mutations of the hepatitis B virus (HBV) and serum TLR2 were evaluated in CHB patients. Fifty-one patients with chronic hepatitis B, negative fo...
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Introduction: The hepatitis B is a viral infection that causes a big problem globally. About 2 billion people worldwide are infected and there are now about 400 million HBV-DNA carriers around the world. HBV infection is the ninth cause of death worldwide and infects about 350 million new cases each year in the world. HBV-DNA can be spotted in different body secretions and fluids, including se...
متن کاملg۱۸۹۶a precore mutation and association with hbeag status, genotype and clinical status in patients with chronic hepatitis b
conclusions our data suggested an intermediate prevalence of g1896a mutation among malaysian hepatitis b carriers. the stop codon mutation has a significant association with genotype b and patients with chronic hepatitis b and liver cirrhosis. patients and methods serum samples from 93 patients confirmed as hepatitis b carriers were collected for molecular assay. the whole genome of hbv was amp...
متن کاملPrecore Codon 28 Stop Mutation in Hepatitis B Virus from Patients with Hepatocellular Carcinoma
OBJECTIVES Hepatitis B virus (HBV) with a stop mutation at precore codon 28 (TGG-->TAG, tryptophan-->stop) was investigated to clarify if such a mutant virus might play a role in hepatocarcinogenesis. METHODS A total of 73 patients with HBV-related hepatocellular carcinoma were included in this study. Polymerase chain reaction (PCR) was performed in DNA samples extracted from 73 sera to ampli...
متن کاملG1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B
BACKGROUND Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over the years, this mutation was not reported much in Malaysia. OBJECTIVES We therefore investigated the presence of G1896A mutation in Malaysian population and its association with HBeAg status, clinical stage, hepatitis B virus (HBV) genotype and e-seroconv...
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ژورنال
عنوان ژورنال: Advances in Virology
سال: 2013
ISSN: 1687-8639,1687-8647
DOI: 10.1155/2013/780319