The polarizable and reprogrammable identity of Kupffer cells in Nonalcoholic Steatohepatitis

Abstract Kupffer cells (KCs) are the resident macrophages of liver with similar origins to myeloid-derived macrophages. Once differentiated, KCs exhibit distinct cellular machinery capable longevity and self-renewal, making them a crucial player in promoting effective intrahepatic communication. However, this gets compromised disease states like Nonalcoholic Steatohepatitis (NASH), where loss embryo-derived (EmKCs) is observed. Despite this, other KC-like KC-derived populations start form contribute variety roles NASH pathogenesis, often adopting NASH-associated molecular signature. Here we offer brief overview recent reports describing KC polarization reprogramming liver. We describe complexities identity, their proposed ability reprogram fibroblast-like endothelial-like cells, potential implications NASH.