The Plasma Erythropoietic Stimulating Factor

The effect of irradiation on the plasma erythropoietic stimulating factor.

With the technieal assi.stan((’ of HELENA K. TAsco’rr T E DEi\IONSTIL\. 1’IOX of erythropoict ic stitnulatory activity ill l)roteitifree “anetnic” plastua extracts by Borsook and his co-workers’ and subsequently by Gordon ct al.2 bias greatly facilitated investigation of the humorab factor or factors capal)le of itiflueticing erythropoiesis. Studies iii this laboratory3 have confirmed the prese...

Evaluation of plasma erythropoietic-stimulating factors in anemic uremic patients.

HE ASSOCIATION of a moderately severe normochromic, normocytic anemia with chronic renal disease is well recognized. Diminished erythropoiesis,’3 hemolysis1’3’4 and hemorrhage5’#{176} have all been shown to contribute to the development of anemia in azotemic patients. However, diminished red cell production appears to be the predominant mechanism in renal anemia. The dynamics of this failure of...

Plasma Erythropoietic Factor in Anemic Human Patients

By T. C. PRENTICE AND E. A. MIIIAND T HE EXISTENCE of a humoral erythropoietic stimulating factor which controls red cell productiomi has been suspected for mnamiy years. Carmiot amid I)eulamidre’ postulated in 1906 that such might be true. Imi 1950 Reissmanm, usimig paral)iotic rats, published convincing experimnental evidemice of a circubatimig erythropoietic factor imiduced by placimig one m...

Studies of plasma erythropoietic factor in anemic human patients.

STUDIES ON THE TISSUE SPECIFICITY OF COLONY STIMULATING FACTOR

In this study granulocyte-macrophage colony stimulating factor (CSF) was prepared from rabbit and guinea pig lung tissues. The biological activity of these CSFs was measured on semisolid agar culture and compared with those of mouse and rat. Weight of animals, incubation time and cross-reactivity of CSFs with different bone marrow sources were also investigated. The results showed that both...