The Phytoestrogen α-Zearalenol Reverses Endothelial Dysfunction Induced by Oophorectomy in Rats
نویسندگان
چکیده
منابع مشابه
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Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. The enhanced nitrative stress plays an important role in homocysteine-induced endothelial dysfunction. Previous studies have showed that phytoestrogen α -zearalanol alleviated endothelial injury in ovariectomized hyperhomocysteinemic rats; however, the underlying mechanism remains to be clarified. This study was to ...
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Zearalenone (ZEA) is a secondary fungal metabolite produced mainly by a Fusarium graminearum. To clarify the toxicokinetics, and residues of ZEA and its major metabolites α-zearalenol (α-ZOL) and β-zearalenol (β-ZOL) in chickens, ZEA was then administered intravenously (iv) or orally (po) to broiler chickens at a dosage of 1.2 mg/kg body weight. The concentrations of ZEA, α-ZOL and β-ZOL in the...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2001
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.3780219