The phytoestrogen genistein suppresses cell-mediated immunity in mice
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منابع مشابه
The role of ISCOMATRIX bilayer composition to induce a cell mediated immunity and protection against leishmaniasis in BALB/c mice
Objective(s):Development of new generation of vaccines against leishmaniasis is possible because long-term protection is usually seen after recovery from cutaneous leishmaniasis. ISCOMATRIX is particulate antigen delivery system composed of antigen, cholesterol, phospholipid and saponin. In this study, the role of ISCOMATRIX bilayer composition made by different phase transition temperature (Tc...
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Yamakido, et al. in 1986 have studied immunological parameters in poison gas workers, and a depression has been observed in immunologic response. Also, the frequency of cancer has reached as high as five-fold that of the general population. In the present study, cell-mediated immunity (CMI) was measured in three groups of Iranian mustard gas-injured patients. The first group were those wh...
متن کاملEVA LUATION OF THE ROLE OF CELL-MEDIATED IMMUNITY IN DERMATOPHYTOSIS
For demonstration of cell-mediated immunity and its role in the process of dermatophytosis, 98 patients with acute dermatophytosis (group I) and 131 chronic dermatophytosis patients (group 2) were chosen. In ail patients, lymphocyte transfonnation and skin test were used. 96 members of group I (98%) had positive delayed-type hypersensitivity (DTH) responses to trichophytin, whereas only 43 ...
متن کاملPermanent Oviduct Posteriorization after Neonatal Exposure to the Phytoestrogen Genistein
BACKGROUND Preimplantation embryo loss during oviduct transit has been observed in adult mice after a 5-day neonatal exposure to the phytoestrogen genistein (Gen; 50 mg/kg/day). OBJECTIVE We investigated the mechanisms underlying the contribution of the oviduct to infertility. METHODS Female mice were treated on postnatal days 1-5 with corn oil or Gen (50 mg/kg/day). We compared morphology,...
متن کاملThe Phytoestrogen Genistein Affects Zebrafish Development through Two Different Pathways
BACKGROUND Endocrine disrupting chemicals are widely distributed in the environment and derive from many different human activities or can also be natural products synthesized by plants or microorganisms. The phytoestrogen, genistein (4', 5, 7-trihydroxy-isoflavone), is a naturally occurring compound found in soy products. Genistein has been the subject of numerous studies because of its known ...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2003
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.0.1760267