The Phytoestrogen Genistein Affects Zebrafish Development through Two Different Pathways
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منابع مشابه
The Phytoestrogen Genistein Affects Zebrafish Development through Two Different Pathways
BACKGROUND Endocrine disrupting chemicals are widely distributed in the environment and derive from many different human activities or can also be natural products synthesized by plants or microorganisms. The phytoestrogen, genistein (4', 5, 7-trihydroxy-isoflavone), is a naturally occurring compound found in soy products. Genistein has been the subject of numerous studies because of its known ...
متن کاملThe effects of the phytoestrogen genistein on the postnatal development of the rat.
The present studies report the effects on neonatal rats of oral exposure to genistein during the period from birth to postnatal day (PND) 21 to generate data for use in assessing human risk following oral ingestion of genistein. Failure to demonstrate significant exposure of the newborn pups via the mothers milk led us to subcutaneously inject genistein into the pups over the period PND 1-7, fo...
متن کاملEffects of the phytoestrogen genistein on the development of the reproductive system of Sprague Dawley rats
OBJECTIVES Genistein is known to influence reproductive system development through its binding affinity for estrogen receptors. The present study aimed to further explore the effect of Genistein on the development of the reproductive system of experimental rats. METHODS Eighteen post-weaning female Sprague Dawley rats were divided into the following groups: (i) a control group that received v...
متن کاملPermanent Oviduct Posteriorization after Neonatal Exposure to the Phytoestrogen Genistein
BACKGROUND Preimplantation embryo loss during oviduct transit has been observed in adult mice after a 5-day neonatal exposure to the phytoestrogen genistein (Gen; 50 mg/kg/day). OBJECTIVE We investigated the mechanisms underlying the contribution of the oviduct to infertility. METHODS Female mice were treated on postnatal days 1-5 with corn oil or Gen (50 mg/kg/day). We compared morphology,...
متن کاملDevelopment of Parallel Auditory Thalamocortical Pathways for Two Different Behaviors
Auditory thalamocortical connections are organized as parallel pathways that originate in different divisions of the medial geniculate body (MGB). These pathways may be involved in different functions. Surprisingly little is known about the development of these connections. Here we review studies of the organization and development of auditory thalamocortical pathways in the pallid bat. The pal...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2009
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0004935