The physiology and pharmacology of postoperative nausea and vomiting

Postoperative nausea and vomiting

Postoperative nausea and vomiting (PONV) is a long-standing issue, not a new concept in anesthesiology. Despite many studies over the last several decades, PONV remains a significant problem due to its complex mechanism. This review presents a summary of the mechanism underlying the pathogenesis of PONV, focusing on preventive treatment, particularly the use of new drugs. In addition, we discus...

Postoperative Nausea and Vomiting

Controlling postoperative nausea and vomiting

Postoperative nausea and vomiting (PNV) in the ambulatory surgical unit is a continuing and vexing problem. Delayed discharges and patient discomfort have major impact in an outpatient setting. An understanding of the causes and aetiologies of PNV including anaesthetic, surgical and patient factors is critically important in the management of these patients. Therapy begins with a good history, ...

The Comparison of Midazolam and Diazepam on Incidence of Postoperative Nausea and vomiting

Abstract Postoperative nausea and vomiting (PONV) is a common and unpleasant complication. Various drugs are used for prevention and treatment of PONV. Recently an antiemetic effect of Lorazepam has been reported, that it's usage as premedication can reduce PONV in children. As Benzodiazepines are safe drugs, their probable antiemetic effect may reduce the usage of other antiemetic drugs with ...

Transdermal hyoscine and postoperative nausea and vomiting.

Forty-two patients, undergoing major gynaecological surgery, were randomly allocated to have a patch applied to the skin behind one ear, containing either hyoscine or placebo. They were followed up at 24-hour intervals for 3 days postoperatively and divided into matched pairs for statistical analysis. There was a significant (p less than 0.01) reduction in nausea and vomiting in the first 24 ho...