THE PHYSIOLOGICAL ACTION OF NEUROMUSCULAR AND GANGLIONIC BLOCKING AGENTS

The influence of certain ganglionic blocking agents on neuromuscular transmission.

GANGLIONIC blockade was first used to produce controlled hypotension during surgery by Scurr (1951). This technique has since become generally accepted in anaesthetic practice. Ganglion blocking drugs now available include the methonium compounds and the short acting agents trimetaphan and homatropinium (Trophenium). There is no doubt that these drugs act selectively on the sympathetic ganglia,...

The Influence of Certain Ganglionic Blocking Agents on Neuromuscular Transmission

GANGLIONIC blockade was first used to produce controlled hypotension during surgery by Scurr (1951). This technique has since become generally accepted in anaesthetic practice. Ganglion blocking drugs now available include the methonium compounds and the short acting agents trimetaphan and homatropinium (Trophenium). There is no doubt that these drugs act selectively on the sympathetic ganglia,...

tracheal intubation without the use of neuromuscular blocking agents

Neuromuscular Blocking Agents

• Neuromuscular blocking agents are used to improve conditions for tracheal intubation, to provide immobility during surgery, and to facilitate mechanical ventilation. • The main site of action of neuromuscular blocking agents (muscle relaxants) is on the nicotinic cholinergic receptor at the endplate of muscle. They also have effects at presynaptic receptors located on the nerve terminal. • Su...

The influence of mecamylamine on the action of certain other ganglionic blocking agents.

RECENT advances in pharmacological knowledge and pharmaceutical techniques have produced a large series of new drugs of low toxicity and few side effects. These advantages together with more specific properties allow their continued use over long periods in the management of chronic disease. At first sight few of these drugs are of direct interest to anaesthetists and consequently tend to be la...