The phenolic compounds of ethanolic extract of date seed (Phoenix dactylifera L.) exert hepatoprotective activity on rat induced carragenan

Background: Hepatotoxic effects can occur with the use of toxic drugs or standard doses, but in long term chronic therapy. In addition to drugs, carrageenan also causes hepatotoxic after 12 hours induction intraperitoneally. The effect liver cell repair is highly related antioxidant activity phenolic compounds date seeds. Objective: present study determined total levels and hepatoprotective ethanol extracts palm seeds (EEBK) carrageenan-induced rats. Method: Determination phenolics extract samples was carried out Folin- Ciocalteu reagent. This pre post-test control group design. Examination SGOT SGPT performed by kinetic method based on IFCC. Data analyzed using paired t-test ANOVA test. Results: content Deglet Noor variety 8.521% GAE. seed dose 150 mg/kg BW showed highest reduction (34.80 U / L). average decrease occurred at a therapeutic 300 16.20 L compared doses 600 bb (11.60 15.60 respectively). Conclusion: 150, 300, had rats as observed from significant decreased (p <0.05). Key word: Date seed, total, extract, SGPT,