The Pharmacological Effects of Bitter Melon
نویسندگان
چکیده
منابع مشابه
Effects of Momordica charantia (Bitter Melon) on Ischemic Diabetic Myocardium.
Objective: A rat model is here used to test a hypothesis that Momordica charantia (Bitter melon (BM)) extract favorably alters processes in cardiovascular tissue and is systemically relevant to the pathophysiology of type 2 diabetes (T2DM) and related cardiovascular disease. Methods: Male Lean and Zucker Obese (ZO) rats were gavage-treated for six weeks with 400 mg/kg body weight bitter melon (...
متن کاملIn vivo antitumor activity of the bitter melon (Momordica charantia).
The in vivo antitumor activity of a crude extract from the bitter melon (Momordica charantia) was determined. The extract inhibited tumor formation in CBA/H mice which had been given i.p. injections of 1.0 X 10(5) CBA/Dl tumor cells (77% of the untreated mice with tumors versus 33% of the treated mice with tumors after 6 weeks). The extract also inhibited tumor formation in DBA/2 mice which had...
متن کاملActivation of AMPK by Bitter Melon Triterpenoids Involves CaMKKβ
We recently showed that bitter melon-derived triterpenoids (BMTs) activate AMPK and increase GLUT4 translocation to the plasma membrane in vitro, and improve glucose disposal in insulin resistant models in vivo. Here we interrogated the mechanism by which these novel compounds activate AMPK, a leading anti-diabetic drug target. BMTs did not activate AMPK directly in an allosteric manner as AMP ...
متن کاملAnti-diabetic and hypoglycaemic effects of Momordica charantia (bitter melon): a mini review.
It has been estimated that up to one-third of patients with diabetes mellitus use some form of complementary and alternative medicine. Momordica charantia (bitter melon) is a popular fruit used for the treatment of diabetes and related conditions amongst the indigenous populations of Asia, South America, India and East Africa. Abundant pre-clinical studies have documented the anti-diabetic and ...
متن کاملLower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients
OBJECTIVE Since antiquity bitter melon has been in use for treating diabetes but clinical trials show conflicting results about its usefulness. The present study aims to asses and compare the hypoglycemic and antiatherogenic effects as well as the safety of two different doses of bitter melon with glibenclamide. METHODS A total of 95 participants were randomized into 3 groups; group I and gro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Dairy & Veterinary Sciences
سال: 2019
ISSN: 2573-2196
DOI: 10.19080/jdvs.2018.08.555747