The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin
نویسندگان
چکیده
منابع مشابه
Variable Platelet Response to Aspirin and Clopidogrel in Atherothrombotic Disease
Humans require rapidly responding, tightly regulated hemostasis because of their closed high-pressure circulatory system. Minor variation in response may predispose to pathological bleeding or thrombosis. In the appropriate setting, pharmacological intervention with antiplatelet therapy stabilizes the atherothrombotic phenotype, though with concomitant hemorrhagic risk. Populations with favorab...
متن کاملReversal of the anti-platelet effects of aspirin and clopidogrel.
BACKGROUND Guidelines recommend stopping aspirin and clopidogrel 7 to 10 days before surgery to allow time for replacement of permanently inhibited platelets by newly released uninhibited platelets. OBJECTIVES The purpose of the present study was to determine the rate of offset of the anti-platelet effects of aspirin and clopidogrel after stopping treatment and the proportion of untreated don...
متن کاملComparison of Triple Anti-Platelet Therapy (Aspirin, Clopidogrel, and Cilostazol) and Double Anti-Platelet Therapy (Aspirin and Clopidogrel) on Platelet Aggregation in Type 2 Diabetic Patients Undergoing Drug-Eluting Stent Implantation
BACKGROUND AND OBJECTIVES Triple anti-platelet therapy may produce more potent inhibition of platelet aggregation in patients undergoing coronary stent implantation. We tested whether this effect could be maintained in diabetic patients, where platelet reactivity is increased and the risk of stent thrombosis is higher. SUBJECTS AND METHODS Fifty five type 2 diabetic patients who had undergone...
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the frame semantic theory is a nascent approach in the area of translation studies which goes beyond the linguistic barriers and helps us to incorporate cognitive and cultural factors to the study of translation. based on rojos analytical model (2002b), which centered in the frames or knowledge structures activated in the text, the present research explores the various translation problems that...
15 صفحه اولcontribution of setting to the study of characters and the main idea in e. brontes: wuthering heights and t. hardys: return of the native.
this thesis aims to adduce an unmitigated and comprehensive explication concerning the relationship of three significant elements of fiction: setting, chracter and theme. my research is basically placed on two outstanding novels of the 19th century: emily brontes wuthering heights and thomas hardys return of the native. my endeavour lies in studying the correlation among the three above-mention...
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ژورنال
عنوان ژورنال: Current Vascular Pharmacology
سال: 2015
ISSN: 1570-1611
DOI: 10.2174/1570161113666150916094829