The Parkinson’s Disease Death Rate: Carbidopa and Vitamin B6 [Retraction]
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منابع مشابه
The Parkinson’s disease death rate: carbidopa and vitamin B6
The only indication for carbidopa and benserazide is the management of L-3,4-dihydroxyphenylalanine (L-dopa)-induced nausea. Both drugs irreversibly bind to and permanently deactivate pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, and PLP-dependent enzymes. PLP is required for the function of over 300 enzymes and proteins. Virtually every major system in the body is impacted direc...
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The importance of hyperhomocysteinemia in the pathogenesis of arteriosclerosis was first recognized by study of vascular pathology in children with homocystinuria caused by 2 different enzymatic abnormalities of homocysteine metabolism.1 Homocystinuria caused by deficiency of cystathionine synthase, a pyridoxal phosphate-dependent enzyme, is characterized by vascular abnormalities and frequent ...
متن کاملVitamin B6 and arteriosclerosis.
In 1949, Rinehart and Greenberg reported that marked arteriosclerosis occurs in vitamin-B6-deficient monkeys. The present study investigates the relationship between vitamin B6 and arteriosclerosis and summarizes the results. I found that thrombogenesis, disorder of collagen metabolism and production of free radicals may be the processes that cause arteriosclerosis in human and experimental ani...
متن کاملHepatic Vitamin B6 Metabolism
nM. Thus, pyridloxal-P is the principal B6 vitaimer in plasma. Durinig pyridoxine stupplemiienitation, mealn plasnma levels of the B6 vitaimers anid pyridoxic acidl increasedl to 655±122 aindl 222±55 nM, respectively. The plasma content of pyridoxal-P aind( pyricloxic acidl increased 6-7-fold anid thatt of pyridoxal, 12-fold, but the pyridloxiine level did niot increase. Isolatedlhepatocytes, 1...
متن کاملPlasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
BACKGROUND Vitamin B(6) has attracted renewed interest because of its role in homocysteine metabolism and its possible relation to cardiovascular risk. We examined the plasma B(6) vitamers, pyridoxal 5'-phosphate (PLP), pyridoxal (PL), pyridoxine (PN), and 4-pyridoxic acid (4-PA) before and after vitamin B(6) supplementation. METHODS Patients (n = 90; age range, 38-80 years) undergoing corona...
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ژورنال
عنوان ژورنال: Clinical Pharmacology: Advances and Applications
سال: 2021
ISSN: 1179-1438
DOI: 10.2147/cpaa.s308256