منابع مشابه
SCIENTIFIC COMMENTARY The other BSE
Brainstem encephalitis has long proved complex and cyptic, but the waters are beginning to clear. Six decades ago, Edwin Bickerstaff (1921–2008), writing from Birmingham with Professor Philip Cloake (1890–1969), described three cases of ‘mesencephalitis and rhombencephalitis’ (Bickerstaff and Cloak, 1951). Each individual presented with a brainstem oculomotor disturbance, other cranial neuropat...
متن کاملChasing the BSE agent
The UK and its anxious neighbours are currently focusing on foot and mouth disease but agricultural researchers are still working on a much deeper and worrying problem: BSE and its human form, new variant CJD. Unlike foot and mouth disease, much remains unknown about the aberrant prion protein agent of BSE and how it causes disease. One of the biggest stumbling blocks to research is the lack of...
متن کاملThe unrecognised French BSE epidemic.
In France, implementation of systematic screening programs in 2000, as a complement to the mandatory reporting of animals with clinical signs of BSE (passive surveillance), revealed certain limitations of the mandatory system. Indeed, systematic screening showed that some BSE cases were not detected by the clinical surveillance system, implying considerable BSE case under-reporting throughout t...
متن کاملConversion of the BASE Prion Strain into the BSE Strain: The Origin of BSE?
Atypical neuropathological and molecular phenotypes of bovine spongiform encephalopathy (BSE) have recently been identified in different countries. One of these phenotypes, named bovine "amyloidotic" spongiform encephalopathy (BASE), differs from classical BSE for the occurrence of a distinct type of the disease-associated prion protein (PrP), termed PrP(Sc), and the presence of PrP amyloid pla...
متن کاملBSE uncertainties drag on
A recent mix-up in studies on brain tissue of animals has set back Britain's efforts to determine human exposure to the BSE agent through contaminated meat products. Nigel Williams reports.
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ژورنال
عنوان ژورنال: Brain
سال: 2011
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awr181