The Origin and Immune Recognition of Tumor-Specific Antigens

Human tumor antigens and specific tumor therapy.

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Effect of Immune Responses Against Hydatid Cyst Antigens on Growth of Melanoma Tumor

Background: Hydatid cyst is the larval stage of the tape worm parasite, Echinococcus granulosus. Human is infected by ingestion of parasite ova excreted in dog feces. The anticancer activity of different antigens of hydatid cyst has been reported in the previous works. In this research, the role of immune system in induction of this anticancer activity has been investigated.Materials and Method...

Tumor-Specific Immune Responses and Present Their Antigens to Elicit Dendritic Cells Capture Killed Tumor Cells

Tumor Rejection Antigens and Immune Surveillance

The existence of specific tumor rejection antigens was first demonstrated with chemically induced mouse sarcomas: each tumor was found to express a different antigen [1]. Similar findings were made with ultraviolet-induced tumors [2]. Later, the generality of the existence of tumor rejection antigens was questioned when spontaneous mouse tumors were found to be completely incapable of eliciting...

Leukemia specific antigens: FOCMA and immune surveillance.

In cats, horizontally transmitted viruses cause leukemia and lymphoma under natural conditions. As with other retroviruses, feline leukemia virus (FeLV) contains products of 3 major genes; the virus core gag gene products, the polymerase, and the virus envelope glycoprotein. When cells are transformed in vitro by the related feline sarcoma virus (FeSV), an additional protein, FOCMA is expressed...