The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism
نویسندگان
چکیده
منابع مشابه
GR89,696 is a kappa-2 opioid receptor agonist and a kappa-1 opioid receptor antagonist in the guinea pig hippocampus.
Receptor binding studies and electrophysiological studies demonstrated the existence of at least two kappa opioid receptors, which have been designated kappa-1 and kappa-2. Several agonists and antagonists are selective for the kappa-1 receptor whereas no known ligands are selective for the kappa-2 receptor. In this study, the kappa opioid GR89,696 was tested in the guinea pig hippocampal slice...
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Orexins (OX-A, OX-B) are neuropeptides involved in the regulation of the sleep-wake cycle, feeding and reward, via activation of orexin receptors 1 and 2 (OX1R, OX2R). The loss of orexin peptides or functional OX2R has been shown to cause the sleep disorder, narcolepsy. Since the regulation of orexin receptors remains largely undefined, we searched for novel protein partners of the intracellula...
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The purpose of the study was to compare the binding energy of pharmacophores of different classes targeting to kappa opioid receptor (KOR) with ketazocine and pentazocine which are having good activity on the KOR. The 3D structure of KOR receptor was built by Homology modeling; pharmacophores were characterized by using Ligand scout. Docking studies for the KOR agonists were performed in Autodo...
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Anne Morinville,1,2 Catherine M. Cahill,2 M. James Esdaile,2 Haneen Aibak,2 Brian Collier,1 Brigitte L. Kieffer,3 and Alain Beaudet2 1Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada H3G 1Y6, 2Montréal Neurological Institute, McGill University, Montréal, Québec, Canada H3A 2B4, and 3Institute of Genetics and of Molecular and Cellular Biology, National Cen...
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ژورنال
عنوان ژورنال: Cellular Signalling
سال: 2015
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2015.03.026