The Ocular Surface Phenotype ofMuc5acandMuc5bNull Mice
نویسندگان
چکیده
منابع مشابه
C57BL/6 mice lacking Muc1 show no ocular surface phenotype.
PURPOSE To test the hypothesis that a membrane-spanning mucin, Muc1, facilitates the spread of tear film and protects against bacterial adherence. METHODS Age-matched, Muc1 null mice and wild-type mice of C57BL/6 genetic background were used for comparison. Eyes were examined by slit lamp biomicroscopy with fluorescein solution to assess epithelial damage and tear film stability. Structure of...
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PURPOSE Fibrillin-2 (Fbn2) is the dominant fibrillin isoform expressed during development of the mouse eye. To test its role in morphogenesis, we examined the ocular phenotype of Fbn2(-/-) mice. METHODS Ocular morphology was assessed by confocal microscopy using antibodies against microfibril components. RESULTS Fbn2(-/-) mice had a high incidence of anterior segment dysgenesis. The iris wa...
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PURPOSE To investigate the compensation of secretory mucins with membranous mucins in mice with goblet cell deficiency. METHODS A transgenic mouse model in which conjunctival goblet cells were targeted was generated, and the expression of mucins was evaluated through the toxicity of diphtheria toxin A driven by a human mucin, MUC5AC, promoter. Immunohistochemical staining, in situ hybridizati...
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Sodium/hydrogen exchanger (NHE) 8 is expressed at the apical membrane of the epithelial cells and plays important roles in neutral sodium absorption in the gastrointestinal tract and the kidney. It also has an important role in epithelial mucosal protection in the gastric gland and the intestine. Although NHE8 has broad tissue distribution, the precise location and the physiological role of NHE...
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Ocular chemical burns are common and serious ocular emergencies that require immediate and intensive evaluation and care. The victims of such incidents are usually young, and therefore loss of vision and disfigurement could dramatically affect their lives. The clinical course can be divided into immediate, acute, early, and late reparative phases. The degree of limbal, corneal, and conjunctival...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2014
ISSN: 1552-5783
DOI: 10.1167/iovs.13-13194