The Number of Markers in the HapMap Project: Some Notes on Chi-Square and Exact Tests for Hardy-Weinberg Equilibrium
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چکیده
منابع مشابه
A note on exact tests of Hardy-Weinberg equilibrium.
Deviations from Hardy-Weinberg equilibrium (HWE) can indicate inbreeding, population stratification, and even problems in genotyping. In samples of affected individuals, these deviations can also provide evidence for association. Tests of HWE are commonly performed using a simple chi2 goodness-of-fit test. We show that this chi2 test can have inflated type I error rates, even in relatively larg...
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15 صفحه اولA consideration of the chi-square test of Hardy--Weinberg equilibrium in a non-multinomial situation.
The multinomial Dirichlet distribution was used to study the effect of correlation between observations in a sample on the frequency of rejection of the Hardy--Weinberg Law when in fact it was true in the population being sampled. It was shown that the usual X2 goodness-of-fit test of Hardy--Weinberg is very sensitive to non-multinomial sampling. In view of the lack of statistical power of the ...
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Exact conditional tests are often required to evaluate statistically whether a sample of diploids comes from a population with Hardy-Weinberg proportions or to confirm the accuracy of genotype assignments. This requirement is especially common when the sample includes multiple alleles and sparse data, thus rendering asymptotic methods, such as the common chi(2)-test, unreliable. Such an exact t...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2010
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2009.11.019