The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide
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چکیده
منابع مشابه
The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide.
BACKGROUND AND PURPOSE It has been previously shown that high levels of nitric oxide (NO), from NO donors, kill neurones, but the mechanisms are unclear. EXPERIMENTAL APPROACH The effects of NO donors on the electrical properties of rat cultured cerebellar granule cells (CGC neurones) were investigated using the whole-cell patch-clamp technique. KEY RESULTS The NO donor (Z)-1-[2-(2-aminoeth...
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Exogenous nitric oxide donors such as DETA NONOate, spontaneously release nitric oxide. This study aimed to investigate the effect of DETA NONOate as a nitric oxide releasing drug on the rate of collagen synthesis during the impaired wound healing in a rat model of diabetes. Twelve male Sprague–Dawley rats were transferred into separate metabolic cages. Nine days before wounding, the rats were ...
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متن کاملthe effect of deta nonoate, a nitric oxide donor, on the rate of collagen synthesis in rat as an animal model of diabetes
exogenous nitric oxide donors such as deta nonoate, spontaneously release nitric oxide. this study aimed to investigate the effect of deta nonoate as a nitric oxide releasing drug on the rate of collagen synthesis during the impaired wound healing in a rat model of diabetes. twelve male sprague–dawley rats were transferred into separate metabolic cages. nine days before wounding, the rats were ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2009
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2009.00400.x