The nitric oxide reductase of enterohaemorrhagic Escherichia coli plays an important role for the survival within macrophages
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چکیده
منابع مشابه
Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages.
The expression of uncoupling protein 2 (UCP2) was reduced in macrophages after stimulation with lipopolysaccharide (LPS). The physiological consequence and the regulatory mechanisms of the UCP2 down-regulation by LPS were investigated in a macrophage cell line, RAW264 cells. UCP2 overexpression in RAW264 cells transfected with eukaryotic expression vector containing ucp2 cDNA markedly reduced t...
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15 صفحه اولPolynucleotide phosphorylase plays an important role in the generation of spontaneous mutations in Escherichia coli.
Polynucleotide phosphorylase (PNP) plays a central role in RNA degradation, generating a pool of ribonucleoside diphosphates (rNDPs) that can be converted to deoxyribonucleoside diphosphates (dNDPs) by ribonucleotide reductase. We report here that spontaneous mutations resulting from replication errors, which are normally repaired by the mismatch repair (MMR) system, are sharply reduced in a PN...
متن کاملConsequences of enterohaemorrhagic Escherichia coli infection for the vascular endothelium.
Microvascular endothelial damage underlies the pathological changes in haemorrhagic colitis and the haemolytic uraemic syndrome (HUS) caused by enterohaemorrhagic Escherichia coli (EHEC). Shiga toxins (Stxs) are presently the best characterised EHEC virulence factors that can cause the microvascular endothelium injury. Stxs are released by EHEC in the intestine, absorbed across the gut epitheli...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2012
ISSN: 0950-382X
DOI: 10.1111/j.1365-2958.2012.08122.x