منابع مشابه
Biosynthesis of penicillins; new crystalline biosynthetic penicillins.
Paper III (1) in this series describes several tests which were found to be useful in determining whether a given compound is utilized by the mold in penicillin formation. To provide proof of the incorporation of various acyl groups into the penicillin molecule and to be able to determine the chemical characteristics and biological properties of the various penicillins, isolation and crystalliz...
متن کاملThe New Penicillins in Endocarditis.
FEW infections can kill a human being as rapidly as acute staphylococcal endocarditis in its most fulminant form. Infections caused by penicillinase producing staphylococci have been particularly difficult to manage. Successful treatment has been 'accomplished by combinations of antibiotics, by vancomycin, and even by huge doses of penicillin G. Still, the problem of therapy remains formidable....
متن کاملSome new biosynthetic penicillins.
In our laboratories some 200 compounds, including phenylacetic acid derivatives, have been studied as possible precursors for new penicillins, and several of these appeared to give rise to new penicillins. In this report, five new penicillins, four of which were obtained in crystalline form, are described and their production, isolation, and characterization discussed. The methods employed in o...
متن کاملAzlocillin and mezlocillin: new ureido penicillins.
The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of other known beta-lactam antibiotics. At a concentration of 25 mug/ml, azlocillin inhibited 74% of Enterobacter, 97% of Proteus mirabilis, 64% of Citrobacter, 91% of Pseudomonas aeruginosa, and 82% of Bacteroides strains tested. Mezlocillin inhibited 86% of Shigella, 96% o...
متن کاملToxicity of the Penicillins.
THE absence of direct toxicity is one of the most remarkable properties of the penicillin molecule; that is to say, the penicillin molecule as we know it and as we should use it. If you try hard enough, you can make it toxic by altering it or abusing it, as I shall try to show later. With this reservation, one can say that penicillin G and the main therapeutic derivatives of 6-aminopenicillanic...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1964
ISSN: 0032-5473
DOI: 10.1136/pgmj.40.suppl.9