منابع مشابه
The cytoskeleton and disease.
Cytoskeletal research in recent years has revolutionized cell biology and biomedicine. The cytoskeleton spans the cytoplasm and interconnects the cell nucleus with the extracellular matrix, thereby forming a structural link between molecules involved in cell communication on the one hand, and gene expression on the other. Since the cytoskeleton is involved in virtually all cellular processes, a...
متن کاملSnapShot: The Bacterial Cytoskeleton
Most bacteria and archaea contain filamentous proteins and filament systems that are collectively known as the bacterial cytoskeleton, though not all of them are cytoskeletal, affect cell shape, or maintain intracellular organization. To view this SnapShot, open or download the PDF.
متن کاملRheology of the Cytoskeleton
The cytoskeleton is the primary internal structure of the cell, providing its structural integrity. The rheology and mechanics of the cytoskeleton, therefore, are key to the cell’s ability to accomplish its diverse functions in health and disease. Although the importance of the cytoskeleton is well established, the relationship between the microstructural details and the macroscopic rheological...
متن کاملEvolution of the cytoskeleton.
The eukaryotic cytoskeleton appears to have evolved from ancestral precursors related to prokaryotic FtsZ and MreB. FtsZ and MreB show 40-50% sequence identity across different bacterial and archaeal species. Here I suggest that this represents the limit of divergence that is consistent with maintaining their functions for cytokinesis and cell shape. Previous analyses have noted that tubulin an...
متن کاملMechanotransduction through the cytoskeleton.
We constructed a model cytoskeleton to investigate the proposal that this interconnected filamentous structure can act as a mechano- and signal transducer. The model cytoskeleton is composed of rigid rods representing actin filaments, which are connected with springs representing cross-linker molecules. The entire mesh is placed in viscous cytoplasm. The model eukaryotic cell is submitted to ei...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2005
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb0205-113