The Natural Estrogenic Compound Diarylheptanoid (D3):In VitroMechanisms of Action andin VivoUterine Responses via Estrogen Receptorα

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The Natural Estrogenic Compound Diarylheptanoid (D3): In Vitro Mechanisms of Action and in Vivo Uterine Responses via Estrogen Receptor α

BACKGROUND Diarylheptanoid (D3) isolated from the medicinal plant, Curcuma comosa, has estrogenic activity. OBJECTIVE We aimed to elucidate the mechanism(s) of D3 action and compare it with that of 17β-estradiol (E2) using both in vitro and in vivo uterine models. METHODS We used human uterine (Ishikawa) cells to determine the estrogenic action of D3 on the activation and nuclear translocat...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 2013

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.1206122