The Na+/I− symporter mediates active iodide uptake in the intestine
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منابع مشابه
The Na+/I- symporter mediates active iodide uptake in the intestine.
Absorption of dietary iodide, presumably in the small intestine, is the first step in iodide (I(-)) utilization. From the bloodstream, I(-) is actively taken up via the Na(+)/I(-) symporter (NIS) in the thyroid for thyroid hormone biosynthesis and in such other tissues as lactating breast, which supplies I(-) to the newborn in the milk. The molecular basis for intestinal I(-) absorption is unkn...
متن کاملTransfer of the human NaI symporter gene enhances iodide uptake in hepatoma cells.
UNLABELLED The characteristic feature of thyroid cells of taking up iodide enables benign thyroid diseases and differentiated thyroid carcinoma to be successfully treated with radioiodide therapy. The transport of iodide across the cell membrane is mediated by the human NaI symporter (hNIS). We therefore investigated whether the accumulation of iodide may be induced by the retroviral transfer o...
متن کاملMonika Paroder and Nancy Carrasco Juan Pablo Nicola , Cécile Basquin , Carla Portulano , Andrea Reyna - Neyra , the intestine The Na + / I - symporter mediates active iodide uptake in
the intestine The Na+/I-symporter mediates active iodide uptake in You might find this additional information useful... is dedicated to innovative approaches to the study of cell and molecular physiology. It is published 12 times AJP-Cell Physiology
متن کاملKinetics of perrhenate uptake and comparative biodistribution of perrhenate, pertechnetate, and iodide by NaI symporter-expressing tissues in vivo.
UNLABELLED Pertechnetate (as (99m)TcO(4)(-)), (123)I(-), and (131)I(-) have a long and successful history of use in the diagnosis and therapy of thyroid cancer, with uptake into thyroid tissue mediated by the sodium-iodide symporter (NIS). NIS has also emerged as a potential target for radiotherapy of nonthyroid malignancies that express the endogenous or transfected symporter. Perrhenates (as ...
متن کاملRadioiodide uptake and sodium iodide symporter expression in breast carcinoma.
Breast cancer is a common malignancy in women all over the world and novel therapeutic approaches are required for the treatment of patients who become refractory to conventional therapies. Thyroid cancer is being treated successfully with radioiodine since many years. The iodide is transported inside the thyroid epithelial cell via sodium iodide symporter (NIS) which is a trans-membrane protei...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2009
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00509.2008