The Musk-Rat in Britain

Great Britain Renal Inactivation of Substance P in the Rat

The activity and distribution of substance P-catabolizing enzyme(s) were studied in the rat kidney. Kidney homogenates inactivate substance P 5-20 times as fast as do homogenates of intestine, liver, lung, heart or brain. The catabolizing activity was highest in the cortex and decreased progressively down the papilla. Cortex of rat kidney was homogenized and fractions enriched in microsomal mem...

Britain Metabolism of Myricetin and Related Compounds in the Rat

1. The metabolism of a group of polyphenols related in structure to myricetin (3,5,7,3',4',5'-hexahydroxyflavone), including myricetin, myricitrin, 3,4,5-trihydroxyphenylacetic acid, delphinidin, robinetin, tricetin, tricin, malvin and 5,7-dihydroxy3',4',5'-trimethoxyflavone, has been studied both in vivo after oral administration to the rat and in vitro in cultures of micro-organisms derived f...

Dermal absorption and disposition of musk ambrette, musk ketone and musk xylene in human subjects.

Musk ambrette, musk ketone and musk xylene have a long history of use as fragrance ingredients, although musk ambrette is no longer used in fragrances. As part of the review of the safety of these uses, it is important to consider the systemic exposure that results from these uses. Since the primary route of exposure to fragrances is on the skin, dermal doses of carbon-14 labelled musk ambrette...

The Elusive Musk Ducks

The toxicology of musk fragrances

Synthetic musk fragrances are widely used as replacements for natural musks not only in perfumes but also in soaps, toiletries and disinfectants. The worldwide annual production of musk fragrances ranges between 6000 and 8000 metric tons per year, of which nitroand polycyclic musks represent 30 and 70%, respectively. As a result of their inherently low biodegradability, nitroand polycyclic musk...