The Multitasking Organ: Recent Insights into Skin Immune Function

Recent Insights Into Ruminant Immune Function: Effects of Stress and Immunostimulatory Nutritional Products

Ruminant livestock are continuously exposed to dangerous pathogens in their environment and, like other animals, rely upon a well-developed immune system to minimize likelihood of an infection. The immune system can be divided into two distinct (yet interacting) systems: 1) the innate immune system and 2) the adaptive or antibodymediated immune system. Generally, we may view the innate system a...

Recent insights into Groucho co-repressor recruitment and function

Gene expression is often controlled by transcriptional repressors during development. Many transcription factors lack intrinsic repressive activity but recruit co-factors that inhibit productive transcription. Here we discuss new insights and models for repression mediated by the Groucho/Transducin-Like Enhancer of split (Gro/TLE) family of co-repressor proteins.

Recent insights into development, metabolic function and therapeutic potential

Fatty acids and immune function: new insights into mechanisms.

Fatty acids are known to play diverse roles in immune cells. They are important as a source of energy, as structural components of cell membranes, as signaling molecules and as precursors for the synthesis of eicosanoids and similar mediators. Recent research has suggested that the localization and organisation of fatty acids into distinct cellular pools has a direct influence on the behaviour ...

Recent insights into C3 glomerulopathy

'C3 glomerulopathy' is a recent disease classification comprising several rare types of glomerulonephritis (GN), including dense deposit disease (DDD), C3 glomerulonephritis (C3GN) and CFHR5 nephropathy. These disorders share the key histological feature of isolated complement C3 deposits in the glomerulus. A common aetiology involving dysregulation of the alternative pathway (AP) of complement...