منابع مشابه
The impact of small RNAs
Introduction Our understanding of the RNA-mediated gene-regulatory pathway, known as RNA interference (RNAi), has come a long way since its discovery in the early 1990s. At that time, all knowledge of RNAmediated silencing was based on one phenomenon: the loss of a non-lethal phenotype after the introduction of exogenous RNA into the affected organism. Since then, various families of non-coding...
متن کاملExploration of Small RNAs
For several decades, only a limited number of noncoding RNAs, such as ribosomal and transfer RNA, have been studied in any depth. In recent years, additional species of noncoding RNAs have increasingly been discovered. Of these, small RNA species attract particular interest because of their essential roles in processes such as RNA silencing and modifications. Detailed analyses revealed several ...
متن کاملDicer-dependent small RNAs
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متن کاملUpdate on Small RNAs
Although most genes use RNA in the form of mRNA as a coding intermediate for protein production, there are many genes whose final products are RNA. These noncoding RNAs range from the familiar transfer and ribosomal RNAs to the more recently discovered regulatory RNAs. One type of regulatory RNA was first discovered during the study of nematode larval development. Two approximately 22nucleotide...
متن کاملSorting Out Small RNAs
Small RNAs carry out their functions by guiding Argonaute (AGO) proteins to their targets. Diverse types of small RNAs and multiple AGO proteins exist in most eukaryotic species, but how small RNAs are sorted into specific AGO complexes remains unclear. Two papers in this issue (Mi et al., 2008; Montgomery et al., 2008) now reveal the importance of the 5' terminal nucleotide of the small RNA in...
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ژورنال
عنوان ژورنال: RNA Biology
سال: 2008
ISSN: 1547-6286,1555-8584
DOI: 10.4161/rna.5.2.5989