The molecular mechanism of CFTR‐ and secretin‐dependent renal bicarbonate excretion

This review summarizes the newly discovered molecular mechanism of secretin-stimulated urine HCO3– excretion and role cystic fibrosis transmembrane conductance regulator (CFTR) in renal excretion. The secretin receptor is functionally expressed basolateral membrane HCO3–-secreting β-intercalated cells collecting duct. Here it activates a fast efficient secretion into serving to normalize metabolic alkalosis. ability acutely increase base entirely dependent on functional pendrin (SLC26A4) CFTR, both proteins localize apical cells. In mice patients, this function absent or markedly reduced. We discuss that alkaline tide, namely transient alkalinity after meal, has now received clear physiological explanation.