The molecular basis of nucleotide excision repair syndromes
نویسندگان
چکیده
منابع مشابه
Human nucleotide excision repair syndromes: molecular clues to unexpected intricacies.
INTRODUCTION THE DEVELOPMENT and maintenance of life has critically depended on the evolution of mechanisms that ensure genetic integrity and stability. DNA, the vital carrier of genetic information, is continually subjected to undesired chemical alterations. Numerous environmental or endogenous compounds and various types of radiation, such as X-rays and ultra-violet (UV) light, induce a wide ...
متن کاملNucleotide excision repair and human syndromes.
DNA damage is implicated in cancer and aging, and several DNA repair mechanisms exist that safeguard the genome from these deleterious consequences. Nucleotide excision repair (NER) removes a wide diversity of lesions, the main of which include UV-induced lesions, bulky chemical adducts and some forms of oxidative damage. The NER process involves the action of at least 30 proteins in a 'cut-and...
متن کاملMammalian nucleotide excision repair and syndromes.
Mammalian nucleotide excision repair and syndromes W. Vermeulcn*, J. de Boer*, E. Citterio*, A. J. van Gool*, G. T. J. van der Horst*, N. G. J. Jaspers*, W. L. dc Laat*, A. M. Sijbers*, P. J. van der Spek*, K. Sugasawa*, G. Weeda*, G. S. Winkler*, D. Bootsma*, J.-M. Egly-land J. H. J. Hoeijmakers. *Department of Genetics, Medical Genetics Centre, Erasmus University, P.O. Box I 738, 3000DR Rotte...
متن کاملMolecular mechanism of nucleotide excision repair.
From its very beginning, life has faced the fundamental problem that the form in which genetic information is stored is not chemically inert. DNA integrity is challenged by the damaging effect of numerous chemical and physical agents, compromizing its function. To protect this Achilles heel, an intricate network of DNA repair systems has evolved early in evolution. One of these is nucleotide ex...
متن کاملMolecular cloning of the human nucleotide-excision-repair gene ERCC4.
ERCC4 was previously identified in somatic cell hybrids as a human gene that corrects the nucleotide-excision-repair deficiency in mutant hamster cells. The cloning strategy for ERCC4 involved transfection of the repair-deficient hamster cell line UV41 with a human sCos-1 cosmid library derived from chromosome 16. Enhanced UV resistance was seen with one cosmid-library transformant and two seco...
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ژورنال
عنوان ژورنال: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
سال: 1994
ISSN: 0027-5107
DOI: 10.1016/0027-5107(94)90273-9