The Molecular and Cellular Mechanisms of Axon Guidance in Mossy Fiber Sprouting

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Molecular mechanisms of axon guidance.

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Mossy fiber sprouting as a potential therapeutic target for epilepsy.

Hippocampal mossy fibers, axons of dentate granule cells, converge in the dentate hilus and run through a narrow area called the stratum lucidum to synapse with hilar and CA3 neurons. In the hippocampal formation of temporal lobe epilepsy patients, however, this stereotyped pattern of projection is often collapsed; the mossy fibers branch out of the dentate hilus and abnormally innervate the de...

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Molecular Biology of Axon Guidance

of a very exciting and intensive meeting that took place The workshop, entitled " Molecular Biology of Axon Guidance, " gathered a forum of 26 speakers and some Spain 90 people in total, who enthusiastically presented and discussed the recent advances in the field. I will summarize the meeting in this review, emphasizing some of the More than a century ago, Cajal published one of his new data p...

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ژورنال

عنوان ژورنال: Frontiers in Neurology

سال: 2018

ISSN: 1664-2295

DOI: 10.3389/fneur.2018.00382