THE MOBILIZATION AND EXTRACELLULAR RELEASE OF GRANULAR ENZYMES FROM HUMAN LEUKOCYTES DURING PHAGOCYTOSIS
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چکیده
منابع مشابه
The Mobilization and Extracellular Release of Granular Enzymes from Human Leukocytes during Phagocytosis
The importance of granular (lysosomal) enzymes from neutrophils in producing the tissue damage of acute inflammation has been suggested by much indirect and some direct evidence. This study has investigated the kinetics of release and subsequent fate of granular enzymes from phagocytizing human leukocytes The following observations are made: (a) During phagocytosis, the granular enzyme lysozyme...
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Washed-cell suspensions of Bacillus amyloliquefaciens secrete significant amounts of the extracellular enzymes alpha-amylase and protease for about 15 min in the almost complete absence of protein synthesis. This apparently represents release of preformed enzyme en route to secretion. The release was independent of energy but was affected by temperature. Pulse-labeling experiments showed that n...
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Human polymorphonuclear leukocytes (PMN) contain three antimicrobial and cytotoxic peptides which belong to a family of mammalian granulocyte peptides named defensins. To determine their potential availability for extracellular microbicidal or cytotoxic events, we quantified the extracellular release of defensins after stimulation of human PMN with phorbol myristate acetate and opsonized zymosa...
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Vinblastine and colchicine interfere with the normal organization of microtubules both in the mitotic spindle of dividing cells-causing metaphase arrest-and in the cytoplasm of nondividing cells such as polymorphonuclear leukocytes, with effects less well understood. In addition to this ultrastructural alteration, coichicine has other morphologic, enzymic, and metabolic effects on phagocytizing...
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Experiments have been performed to determine some of the factors affecting the release of intracellular enzymes, in the hope of improving our understanding of the mechanisms whereby tissue enzymes reach the circulation in disease processes. The discharge of intracellular enzymes into the medium during prolonged incubation of human leukocytes and rat lymphocytes has been shown to be inversely re...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1972
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.53.3.788