The mitotic origin of chromosomal instability
نویسندگان
چکیده
منابع مشابه
The mitotic origin of chromosomal instability
chromosomes, with only 2–6% anaphase CIN-cells displaying lagging chromosomes compared to 12–17% anaphase CIN+ cells (Figure 1B). CIN+ cells also contained multiple lagging chromosomes per anaphase, whereas multiple lagging chromosomes were rarely observed in CIN-cells (not shown). Very few acentric fragments were observed in anaphase for both CIN-and CIN+ cells, and this result was also confir...
متن کاملUp-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons.
The mitotic checkpoint is the major cell cycle checkpoint acting during mitosis to prevent aneuploidy and chromosomal instability, which are hallmarks of tumor cells. Reduced expression of the mitotic checkpoint component Mad1 causes aneuploidy and promotes tumors in mice [Iwanaga Y, et al. (2007) Cancer Res 67:160-166]. However, the prevalence and consequences of Mad1 overexpression are curren...
متن کاملMechanisms of Chromosomal Instability
Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon called chromosomal instability (CIN). CIN positively correlates with poor patient prognosis, indicating that reduced mitotic fidelity contributes to cancer progression by increasing genetic diversity among tumor cells. Here...
متن کاملDelayed replication timing leads to delayed mitotic chromosome condensation and chromosomal instability of chromosome translocations.
Chromosomal rearrangements are found in virtually all types of human cancers. We show that certain chromosome translocations display a delay in mitotic chromosome condensation that is associated with a delay in the mitosis-specific phosphorylation of histone H3. This delay in mitotic condensation is preceded by a delay in both the initiation as well as the completion of chromosome replication. ...
متن کاملIncreased expression of mitotic checkpoint genes in breast cancer cells with chromosomal instability.
PURPOSE Most breast cancers have chromosomal instability that seems related to defective mitotic spindle checkpoints. Because the molecular basis of this defect is unknown, we evaluated breast cancer cell lines and tissues for possible defects involving the major mitotic checkpoint genes responsible for maintaining chromosomal stability. EXPERIMENTAL DESIGN We analyzed sequences and expressio...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2014
ISSN: 0960-9822
DOI: 10.1016/j.cub.2014.01.019