The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumourigenesis
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چکیده
منابع مشابه
REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis
The transcription factor GATA6 is a critical regulator of cell proliferation and development in the gastrointestinal tract. We have recently reported that GATA6 induces the expression of the intestinal stem cell marker LGR5 and enhances the clonogenicity and tumorigenicity of colon cancer cells, but not the growth of these cells cultured under adherent conditions. Here we show that REG4, a memb...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms4150