The micronucleus test—most widely used in vivo genotoxicity test—
نویسندگان
چکیده
منابع مشابه
The micronucleus test as an in vivo cytogenetic method.
Methods are currently being explored which would permit the application of cytogenetic procedures such as metaphase and anaphase analyses to in vivo mammalian systems in order that due consideration may be given to metabolic activation or detoxification reactions which might affect the mutagenic or clastogenic (chromosome breaking) potential of environmental agents under study. It has been reco...
متن کاملThe new ISSMIC database on in vivo micronucleus and its role in assessing genotoxicity testing strategies.
This paper presents a new curated database on in vivo micronucleus mutagenicity results, called ISSMIC. It is freely available at: http://www.iss.it/ampp/dati/cont.php?id=233&lang=1&tipo=7. The experimental results were critically reviewed, and evidence on target cell exposure was considered as well. The inspection of ISSMIC demonstrates that a large proportion of reported negative results in t...
متن کاملGenotoxicity evaluation in chronic renal patients undergoing hemodialysis and peritoneal dialysis, using the micronucleus test.
Patients with chronic renal disease have an increased incidence of cancer. It is well known that long periods of hemodialysis treatment are linked to DNA damage due to oxidative stress. This genotoxic effect may cause the loss of chromosome fragments, or even entire chromosomes, which form micronuclei after cell division, and can be detected by the micronucleus test. In the present case-control...
متن کاملThe bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)
The mouse (Mus musculus) bone marrow micronucleus test was carried out using 24 outbred National Institutes of Health (NIH) mice, 24 inbred Swiss Webster (CFW) mice and 20 inbred Bagg albino/color locus Jackson (BALB/cJ) mice. The mice in the experimental group (n = 32) were injected intraperitoneally with 133 mg kg of metronidazole parenteral solution and the control group consisted of mice (n...
متن کاملOccupational genotoxicity risk evaluation through the comet assay and the micronucleus test.
The micronucleus (MN) test and the alkaline single cell gel or comet assay were applied to exfoliated cells of the buccal mucous in order to evaluate the genotoxic risk associated with occupational exposure of 10 storage battery renovation workers, and 10 car painters, with age matched controls, in Pelotas, RS, in southern Brazil. In the MN test, 2000 exfoliated buccal cells were analyzed for e...
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ژورنال
عنوان ژورنال: Genes and Environment
سال: 2016
ISSN: 1880-7062
DOI: 10.1186/s41021-016-0044-x